Cilostazol 50mg bula - Pletal (cilostazol) Drug Side Effects, Interactions, and Medication Information on eMedicineHealth.

The displacement of Cilostazol from plasma proteins by erythromycin, quinidine, warfarin, and omeprazole was not clinically significant. Metabolism Cilostazol is eliminated predominantly by metabolism and subsequent urinary excretion bula metabolites.

The enzyme responsible for metabolism of 3,4-dehydro-Cilostazol, the most active of the metabolites, cilostazol 50mg bula, is unknown.

There was no evidence of induction of hepatic microenzymes. Special Populations Age and 50mg The total and unbound cilostazol clearances, adjusted for body weight, of Cilostazol and its metabolites cilostazol not significantly different with respect to age 50 to 80 50mg or gender.

Hepatic Impairment The pharmacokinetics of Cilostazol and its metabolites were similar in subjects with bula hepatic disease as compared to healthy subjects.

cilostazol 50mg bula

Patients with moderate or severe hepatic impairment have not been studied. Renal Impairment The total pharmacologic activity of Cilostazol and its metabolites was similar in subjects with mild to moderate renal impairment and in healthy subjects. Severe renal bula increases metabolite levels and alters protein binding of the parent. The expected pharmacologic activity, however, based on plasma concentrations and relative PDE III inhibiting potency of parent drug and metabolites, appeared little changed.

Cilostazol did not inhibit the metabolism of R- and S-warfarin after a single mg dose of warfarin. Multiple doses of clopidogrel do not significantly increase steady state plasma concentrations of Cilostazol.

A priming dose of ketoconazole mg a strong inhibitor of CYP3A4was 50mg one day prior to coadministration of single doses of ketoconazole mg and Cilostazol mg. Other strong inhibitors of CYP3A4, such as itraconazole, voriconazole, clarithromycin, ritonavir, saquinavir, and nefazodone would be expected to have a similar effect [see 50mg and Administration 2. Erythromycin and other macrolide antibiotics: Erythromycin is a moderately strong inhibitor of CYP3A4.

Concomitant administration of quinidine with a single dose of Cilostazol mg did not alter Cilostazol pharmacokinetics. There is also a decrease, although nonsignificant, in Cilostazol metabolite concentrations. The maximum doses administered in both rat and mouse studies were, cilostazol 50mg bula, on a systemic exposure basis, less than the human exposure at the MRHD of the drug. Cilostazol tested negative in bacterial gene cilostazol, bacterial DNA repair, cilostazol 50mg bula, mammalian cell gene mutation, bula mouse in vivo bone marrow chromosomal aberration assays.

It was, however, associated with a significant increase in chromosomal aberrations in the in vitro Chinese Hamster Ovary Cell assay. If you forget to take Cilostazol If you miss a dose, do not worry; wait until the next cilostazol to take your next tablet and then carry on as normal. DO NOT take a double dose to make up for a forgotten tablet. If you stop taking Cilostazol If you stop taking Cilostazol the pain in your legs may come back or get worse.

Therefore, you should only stop taking Cilostazol if you notice side effects requiring urgent medical attention see section 4 or if your doctor tells you to.

Possible side effects Like all medicines, Cilostazol can cause side effects, although not everybody gets them.

If any of the following side effects happen, cilostazol 50mg bula, you may need urgent medical attention. Stop taking Cilostazol and contact a doctor or go to the nearest hospital immediately. Absolute bioavailability is not known. Cilostazol is extensively cilostazol by hepatic cytochrome P enzymes, mainly 3A4, and, to a lesser extent, 2C19, with metabolites largely excreted in urine.

Pharmacokinetics are approximately dose proportional. Cilostazol and its active metabolites have apparent elimination half-lives of about hours. Cilostazol and its active metabolites accumulate about 2-fold with chronic administration and reach steady state blood levels within a few days.

The pharmacokinetics of cilostazol and its two major active metabolites were similar in healthy subjects and patients bula intermittent claudication due to peripheral arterial disease PAD. 50mg 1 shows the mean plasma concentration-time profile at steady state after multiple dosing of PLETAL mg twice daily. The binding for 3,4-dehydro-cilostazol is Mild hepatic impairment did not affect protein binding.

The displacement of cilostazol from plasma proteins by erythromycinquinidine, warfarin, and omeprazole was not clinically significant.

cilostazol

Metabolism Cilostazol is eliminated predominantly by metabolism and subsequent urinary excretion of metabolites. The enzyme responsible for metabolism of 3,4-dehydro-cilostazol, cilostazol 50mg bula, the most active of the metabolites, cilostazol 50mg bula, is unknown. There was no evidence of induction of hepatic microenzymes. Special Populations Age And Gender The total and unbound cilostazol clearances, adjusted for body weight, of cilostazol and its metabolites were not significantly different with respect to age 50 cilostazol 80 years or gender, cilostazol 50mg bula.

Hepatic Bula The pharmacokinetics of bula and its metabolites were similar bula subjects with 50mg hepatic disease as compared to healthy subjects. Patients with moderate or severe hepatic impairment have not been studied.

Renal Impairment The total pharmacologic activity of cilostazol and its metabolites was similar in subjects with mild to moderate renal impairment and in healthy subjects. Severe renal impairment increases metabolite levels and alters protein binding of the parent.

The expected cilostazol activity, however, based amitriptyline 10mg teeth grinding plasma concentrations and relative PDE 50mg inhibiting potency of parent drug and metabolites, appeared little changed.

Warfarin Cilostazol did not inhibit the metabolism of R-and S-warfarin after a single mg dose of warfarin. Clopidogrel Multiple doses of clopidogrel do not 50mg increase steady state plasma concentrations of cilostazol.

Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

cilostazol 50mg bula

50mg and grapefruit juice may interact with cilostazol. The interaction could lead to bula dangerous effects. Discuss the use of grapefruit products with your doctor. cilostazol

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Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. Take cilostazol on an empty stomach, at least 30 minutes before or 2 hours after food. What should I discuss with my healthcare provider before taking cilostazol Pletal? Before using cilostazol, tell your doctor if you have: If you have any of these conditions, you may need a dose adjustment or special tests to safely take this medication, cilostazol 50mg bula.

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